刘世建

一、个人信息

姓名：刘世建

职称：研究员

类别：硕士、博士研究生导师

研究方向：海南气候环境因素对候鸟老人和儿童哮喘等过敏性疾病的影响及其机制研究、性早熟与肥胖的共病机制研究

二、教育经历

第三军医大学  临床医学系  本科

第二军医大学  基础医学院神经生物学  硕士

第二军医大学  流行病与卫生统计学  博士

美国密西西比大学医学中心  访问学者

三、主要工作经历

2022.1-2025.3   上海儿童医学中心海南医院  大数据中心  主任

            上海交通大学  公共卫生学院   博士生导师

            上海儿童医学中心  儿科转化医学研究所  PI

四、学术成果

【近五年主持的省部级以上课题】

1.国家自然科学基金面上项目，外源性类固醇激素对肥胖女童性早熟的影响和机制研究，82173534，2022.1-2025.12，在研，主持。

2.国家自然科学基金面上项目，肥胖及其风险基因多态性影响女童性早熟的机制研究，81872637，2019.01-2022.12，结题，主持。

3.上海市卫计委临床研究专项课题，肥胖风险基因多态性对女童性早熟影响的病例对照研究，2019.01-2021.12，结题，主持。

4.浦东新区科技发展基金民生科研项目，环境暴露与DNMT基因多态性在先天性心脏病发生中的交互作用研究，2017.11-2020.10，结题，主持。

【近五年以第一或通讯作者发表SCI论文】

1.Jingyi Tang,Yao Chen,Peng Xue,Yang Chen,Huijun Kong,Cuilan Lin,Xiumin Wang,Shijian Liu*.Exposure to synthetic steroid hormones and precocious puberty in girls:A case-control study.Ecotoxicology and Environmental Safety (IF=6.2,JCR Q1,中科院1/2区).2024,283:116814.DOI:10.1016/j.ecoenv.2024.116814.（最后通讯作者）

2.Yabin Hu#,Guiyan Yang#,Dan Wang,Wangyang Gu,Dan Xie,Tingyue Huang,Peng Xue,Jingyi Tang,Hui Wei,Shenghui Li,Shilu Tong,Shijian Liu*.Associations of insecticides exposure with childhood asthma and wheezing–the wave I of a prospective cohort study in Sanya,China.Toxics(IF4.6,Q1,中科院3区).Accepted on May 23,2024.DOI:10.3390/toxics12060392.PMID:38922071.（最后通讯作者）

3.Peng Xue#,Jianfei Lin,Jingyi Tang,Tingting Yu,Chang Chen,Yao Chen, Huijun Kong,Cuilan Lin,Shijian Liu*.Association of obesity and menarche SNPs and interaction with environmental factors on precocious puberty.Pediatric Research(IF3.6,Q1,中科院3区).2024.DOI:10.1038/s41390-024-03168-6.PMID: 38649724.（最后通讯作者）

4.Xinlin Chen#,Simao Fu#,Chaojun Chen,Yawen Yuan,Zhibin Dai,Ang Chen, Bihong Zhang,Shijian Liu*,Cuilan Lin*.Association of traditional dietary patterns on early and precocious puberty:A population-based cross-sectional study. Pediatric Research (IF3.6,Q1,中科院3区).2024.96(1):245-252.DOI:10.1038/s41390-024-03110-w.PMID:38431666.(共同通讯作者)

5.Peng Xue#,Dan Wang#,Jingyi Tang,Yang Chen,Yao Chen,Hao Mei,Cuilan Lin*,Shijian Liu*.Association between body fat distribution and age at menarche:A two sample Mendelian randomization study.Frontiers in Pediatrics (IF2.6,Q2).2024,12:1349670.DOI:10.3389/fped.2024.1349670.PMID: 38650991.（最后通讯作者）

6.Xinyu Wu,Lingmei Wang,Peng Xue,Jingyi Tang,Haodong Wang,Huijun Kong, Cuilan Lin,Bo Chang*,Shijian Liu*.Association of screen exposure/secondary behavior and precocious puberty/early puberty. Frontiers in Pediatrics (IF3.2, JCR Q2/4区). Accepted on September7,2024.（最后通讯作者）

7.Jingyi Tang#,Tingting Yu#,Yanrui Jiang,Peng Xue,Huijun Kong,Cuilan Lin*, Shijian Liu*,Ying Tian*.The association between sleep and precocious puberty in Chinese children:A school population-based cross-sectional study.Frontiers in Endocrinology(IF5.2,Q1/2,中科院2区).2023,14:1259172.DOI: 10.3389/fendo.2023.1259172.PMID: 38075047.(共同通讯作者)

8.Qian Hu#,Guiyan Yang#,Dan Wang,Yongzhen Huang,Jiashi Gao,Haidao Guan,Han Ren, Xiaoya Lin,Shilu Tong,Xiufeng Shi*,Shijian Liu*.Effects of climate and environment on migratory old people with allergic diseases in China:Protocol for a Sanya cohort study.Heliyon (IF4.0,Q2).2023, 9(11):e21949. DOI:10.1016/j.heliyon.2023.e21949.PMID: 38045199.(最后通讯作者)

9.Haidao Guan#,Guiyan Yang#,Jiashi Gao,Xiaoya Lin,Chao Liu,Han Ren,Duyue Chen,Lingyao Zhou,Qian Hu,Yongzhen Huang,Yumei Zhao,Shilu Tong,Zhaohui Lu, Shijian Liu*,Dan Wang*.Sanya climatic-treatment cohort profile:Objectives, design, and baseline characteristics. Frontiers in Public Health 2023.(IF 5.2, Q1,中科院3区)2023,11:1290303.DOI:10.3389/fpubh.2023.1290303.PMID: 37927865.(共同通讯作者)

10.Xiaoqing Li#,Weiyu Liu #,Weiming Kong,Wenqing Zhao,Hansong Wang,Dan Tian,Jiali Jiao,Zhangsheng Yu*,Shijian Liu*.Prediction of Outpatient Waiting Time Using Machine Learning in a Tertiary Children Hospital.Translational Pediatrics（IF2.0,Q3）.2023,12(11):2030-2043.DOI:10.21037/tp-23-58.PMID: 38130586(最后通讯作者)

11.Zijie Jin, Yan Yuan,Chen Zheng,Shijian Liu*,Hongbo Weng*.Effects of sodium-glucose co-transporter 2 inhibitors on liver fibrosis in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: An updated meta-analysis of randomized controlled trials.Journal of Diabetes and Its Complications (IF3.0,Q3).2023;37(8):108558. DOI:10.1016/j.jdiacomp.2023.108558. PMID: 37499274.(共同通讯作者)

12.Jingyi Tang,Peng Xue,Xiaoxia Huang,Cuilan Lin*,Shijian Liu*.Diet and nutrients intakes during infancy and childhood in relation to early puberty:A systematic review and meta-analysis.Nutrients (IF5.9，Q1，中科院2区).2022, 14(23):5004.DOI:10.3390/nu14235004.PMID: 36501034.(最后通讯作者)

13.Hongxia Wang,Meixiang Zhao,Shijian Liu*,Xuefeng Wang*.Efficacy and safety of reduning injection combined with azithromycin in the treatment of mycoplasma pneumonia among children:A systematic review and meta-analysis. Phytomedicine (IF7.9，Q1,中科院1区).2022;106:154402.DOI: 10.1016/j.phymed.2022.154402. PMID: 36029644(共同通讯作者)

14.Xiaoqing Li#,Dan Tian#,Yabin Hu,Weihua Li,Bin Dong,Hansong Wang,Jiajun Yuan,Biru Li,Hao Mei,Shilu Tong,Liebin Zhao*,Shijian Liu*.Using artificial intelligence in queuing time and satisfaction:a randomized clinical trial. Frontiers in Pediatrics (IF2.6,Q2).2022;10:929834.DOI: 10.3389/fped.2022.929834.PMID:36034568.(最后通讯作者)

15.Peng Xue#,Yirou Wang#,Yao Chen,Xiaoyu Wu,Yijun Tang,Yu Ding,Xiumin Wang*, Shijian Liu*.A case of peripheral precocious puberty may be caused by a diet containing phytosterols in a 20-month-old boy. Hormone Research in Paediatrics (IF3.2,Q1/Q2，中科院3区).2022.95(5):484–491.DOI:10.1159/000526202. PMID:36041401.(最后通讯作者)

16.Yawen Zhang#,Jianmin Ni#,Lei Zhang,Tingting Yu,Xiaoqing Li,Peng Xue, Yifan Liu,Bo Gao,Xinwen Xue,Huijun Kong*,Shijian Liu*.The prevalence of precocious puberty among children in Qufu City,Shandong Province, China,A population-based study.Frontiers in Endocrinology (IF5.2,Q1,中科院2区). 2022;13:910119.DOI:10.3389/fendo.2022.910119.(最后通讯作者)

17.Yi Hu,Qi Lu,Chuican Huang,Yu Gao,Ying Tian*,Lichun Fan*,Shijian Liu*. Associations between prenatal exposure to polybrominated diphenyl ethers and physical growth in a seven year cohort study. Chemosphere (IF8.8,Q1,中科院2区).2022,303(Pt1):135049.DOI:10.1016/j.chemosphere.2022.135049. PMID:35618052.(最后通讯作者)

18.Tingting Yu#,Ying Yu#,Xiaoqing Li,Peng Xue,Xiaodan Yu,Yao Chen,Xiumin Wang,Bo Chang,Huijun Kong,Cuilan Lin,Hao Mei,Dan Wang*,Shijian Liu*. Effects of childhood obesity and related genetic factors on precocious puberty: protocol for a multi-center prospective cohort study.BMC Pediatrics (IF 2.4, Q3).2022,22(1):310.DOI:10.1186/s12887-022-03350-x.PMID:35624438.(最后通讯作者)

19.Yabin Hu #,Juan Li#,Tao Yuan,Tingting Yu,Yao Chen,Huijun Kong,Cuilan Lin, Zhemin Shen,Ying Tian,Shilu Tong,Xiaodan Yu*,Shijian Liu*.Exposure to antibiotics and precocious puberty in children:a school-based cross-sectional study in China.Environmental Research (IF8.3,Q1,中科院2区).2022,212(Pt C):113365.DOI:10.1016/j.envres.2022.113365.PMID:35490828.(最后通讯作者)

20.Yao Chen#,Jianyong Chen#,Yijun Tang,Qianwen Zhang,Yirou Wang, Qun Li,Xin Li,Zihan Weng,Ju Huang,Xiumin Wang*,Shijian Liu*.Difference of precocious puberty between before and during the COVID-19 pandemic:A cross-sectional study among Shanghai school-aged girls.Frontiers in Endocrinology (IF5.2,Q1,中科院2区).2022,13:839895.DOI:10.3389/fendo.2022.839895.PMID:35392135.(最后通讯作者)

21.Hongxiang Gao#,Baige Cao#,Nan Dang#,Song Gu,Min Xu,Bin Ji,Yiqi Shi, Shijian Liu*,Congrong Wang*.Comparison of factors influencing the willingness to donate biospecimens among guardians of children with cancer and adult cancer patients.Cancer Medicine (IF4.0,Q2).2022,11(6):1524-1534. DOI:10.1002/cam4.4544.PMID:35112506.(共同通讯作者)

22.Dongxue Pan#,Simao Fu#,Xiaoqing Li,Tingting Yu,Sizhe Huang,Bihong Zhang,Xin Lai,Yifan Liu,Xiaodan Yu,Cuilan Lin*,Shijian Liu*.The concordance between ultrasonographic stage of breast and Tanner stage of breast for overweight and obese girls:A school population-based study.Journal of Pediatric Endocrinology and Metabolism(IF1.520,Q3).2021,34(12):1549-1558.DOI: 10.1515/jpem-2021-0181.PMID:34492746. (最后通讯作者)

23.Xin Lai#,Simao Fu#,Jianfei Lin,Sizhe Huang,Tingting Yu,Xiaoqing Li, Xiaodan Yu,Xiaowen Feng,Cuilan Lin*,Shijian Liu*.Association of obesity and body fat percentage with pubertal state in six-to nine-year-old Chinese females.Childhood obesity (IF2.867,Q2).2021,17(8):525-533. DOI:10.1089/chi.2020.0247.PMID:34190651.(最后通讯作者)

24.Xiaoqing Li#,Dan Tian#,Weihua Li,Bin Dong,Hansong Wang,Jiajun Yuan,Biru Li,Lei Shi,Xulin Lin,Liebin Zhao*,Shijian Liu*.Artificial intelligence-assisted reduction in patients’waiting time for outpatient process:A retrospective cohort study.BMC Health Services Research (IF:2.908,Q3)2021, 21(1):237.DOI:10.1186/s12913-021-06248-z.PMID:33731096.(最后通讯作者)

25.Xiaoqing Li#,Jiang Han#,Shaodian Zhang,Ken Chen,Liebin Zhao,Yi He*, Shijian Liu*.Artificial Intelligence for Screening Chinese Electronic Medical Record and Biobank Information.Biopreservation and Biobanking(IF2.256,Q3). 2021;19(5):386-393.DOI:10.1089/bio.2020.0151.PMID:34042506.(最后通讯作者)

五、学术兼职

Nature communications, Pediatrics，《第二军医大学学报》、《中南大学学报》等期刊审稿人

中国医药生物技术协会组织生物样本库分会儿科学组秘书长

中国妇幼保健协会妇儿生物样本及生物信息数据研究与应用分会常委

中国抗癌协会肿瘤样本整合研究分会常委

生物样本库国家工程中心专家组成员

中华预防医学会儿少卫生分会委员

中华预防医学会儿童慢病防治工作委员会委员

中国医师协会儿科分会流行病学学组委员

中国学生营养与健康促进会体医融合学生健康分会委员

上海市临床流行病学与循证医学分会委员

中国医师协会肥胖学组委员

《中国学校卫生》杂志常务编委

六、研究生培养概况 

从2014年至今已经培养毕业研究生11名，目前指导海南医科大学和上海交通大学在读研究生8名。与合作单位联合培养5名，主要是南方医科大学和大连医科大学的研究生。培养研究生中有3名获国家奖学金，4名获上海交通大学优秀毕业生。本课题组具有良好的学习氛围，为每位学生制定研究计划，报考本导师能够共享上海交通大学医学院的优质教学资源，欢迎各位有志青年报考。

七、联系方式

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